ERTAPENEM PACKAGE INSERT PDF

For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

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Your Name Your name is required. Major Concomitant use of carbapenems doripenem, ertapenem, imipenem, meropenem and valproic acid is not recommended. If possible, avoid coadministration.

In vitro studies have also retapenem that it does not inhibit p-glycoprotein-mediated transport of digoxin or vinblastine. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. For the treatment of complicated intraabdominal infections. Carbapenems can reduce serum concentrations of valproic acid to subtherapeutic levels eertapenem the two ihsert are administered together.

Intravenous or Intramuscular dosage. Agitate well to form a solution. If ertapenem is given within 6 hours of hemodialysis, a supplementary dose of mg is recommended following the hemodialysis session. Ertapenem distributes into human breast milk and crosses the rat placental barrier.

PBPs are responsible for several steps in the synthesis of the cell wall and are found in quantities of several hundred to several thousand molecules per bacterial cell.

Like meropenem, but unlike imipenem, it has a 1-beta-methyl substituent and does not require protection with an inhibitor of human renal dihydropeptidase I.

Ertapenem for Injection — AuroMedics Pharma LLC

If focal tremor or myoclonic seizures occur, patients should be evaluated neurologically. In setting of a cat or dog bite, preemptive antimicrobial therapy is recommended for 3 to 5 days for patients who are immunocompromised, asplenic, have advanced liver disease, have edema of the bite area, have moderate to severe injuries, particularly of the hand or face, or have penetrating injuries to the periosteum or joint capsule.

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Antibiotics are non-selective and may result in the eradication of beneficial microorganisms while promoting the emergence of undesired ones, causing secondary infections such as oral thrush, colitis, or vaginitis.

If diarrhea develops during therapy, the drug should be discontinued. IV or IM broad-spectrum carbapenem antibiotic stable against beta-lactamases Used to treat UTI, skin, pelvic, intraabdominal infections and community-acquired pneumonia; used for colorectal surgical prophylaxis Once-daily dosing may be advantageous, but no P.

It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in enterohepatic circulation via changes in GI flora.

No intraoperative redosing and duration of prophylaxis less than 24 hours are suggested by clinical practice guidelines. Most patients with skin and soft tissue infections do well with 1 to 2 weeks of therapy. Activity is maintained by the parent drug until the beta-lactam ring is hydrolyzed resulting in an inactive metabolite.

Your email has been sent. It is eliminated via the kidney with a prolonged half-life of roughly 4. If the drugs are coadministered and serum valproic acid concentrations cannot be maintained or if seizures occur, alternative antibacterial or anticonvulsant therapy should be considered.

It is known that systemic use of antibiotics predisposes patients to development of pseudomembranous colitis. For the treatment of acute pelvic infections, including postpartum endomyometritis, septic abortion, and postsurgical gynecologic infections.

Additionally, increased monitoring of the INR, especially during initiation and upon discontinuation of the antibiotic, may be necessary. Send the page ” ” to a friend, relative, colleague or yourself. Colitis, diarrhea, GI disease, inflammatory bowel disease, pseudomembranous colitis, ulcerative colitis.

Ertapenem should be prescribed with caution to patients with inflammatory bowel disease such inssrt ulcerative colitis or other GI disease. Do not co-infuse with other medications.

Immediately transfer the appropriate amount of the reconstituted vial to diluent. No data are available regarding use in pediatric patients with renal impairment.

In vitro and in vivo animal studies have demonstrated that the major pharmacodynamic parameter that determines efficacy for beta-lactams is the amount of time free non-protein bound drug concentrations exceed the minimum inhibitory concentration MIC of the organism free T above the MIC.

Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. The MICs are defined for Staphylococcus sp. Patients at greater risk packave seizures may include: Further dilution is srtapenem for IV infusion. PBPs vary among different bacterial species. Therefore, these antibiotics should be taken at least 2 hours before and not less than 6 hours after the administration ettapenem sodium picosulfate; magnesium oxide; anhydrous citric acid solution.

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Accumulation does not occur following multiple IM doses in healthy adults. Products inhibiting peristalsis are contraindicated in this clinical situation.

Ertapenem is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified.

Following diagnosis of pseudomembranous colitis, therapeutic measures should be instituted. The exact mechanism of this interaction is not known, however, based on in vitro and animal data, inhibition of valproic acid glucuronide hydrolysis is a suggested mechanism.

Complete the infusion within 6 hours of reconstitution. Use within 1 hour after preparation.

Ertapenem Sodium Injection – Par Sterile Products – Products

The IM reconstituted formulation is not for IV use. Patients who have experienced anaphylactic reactions to penicillins or cephalosporins should not receive ertapenem. Ertapenem is administered via intravenous IV or intramuscular IM routes. Ertapenem exhibits bactericidal activity due inhibition of cell wall synthesis mediated via binding to penicillin binding proteins PBPs.

Any antibiotic may cause diarrhea, nausea, vomiting, anorexia, and hypersensitivity reactions. Anticonvulsant therapy should be initiated if indicated and the dose of ertapenem should be re-evaluated based on the patient’s renal function.