Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.

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This article has been cited by other articles in PMC. Past medical history revealed that patient was known case of epilepsy since 7 years of age and was on tablet eptoin, tablet carbamazepine for past 12 years. Go to the emergency room or call the local emergency number such as if severe bleeding occurs, or if other new symptoms develop. N Engl J Med ; Hemolytic disease of the newborn. Platelet transfusions may be used in severe bleeding together with a very low count.

Immune thrombocytopenic purpura

In chronic trombositpenia cases, where immune pathogenesis has been confirmed, [15] the off-label use of the vinca alkaloid [16] [17] [18] and chemotherapy agent vincristine may be attempted. Diabetes mellitus type 1 Hashimoto’s thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis. Immune thrombocytopenia, neonatal alloimmune thrombocytopenia, and posttransfusion purpura.

Extraoral examination revealed petechial spots over the neck on right side [ Figure 1 ], petechial spots over the forearms, and petechial spots over the right arm [ Figure 2 ]. Recent trombositopebia now indicates that impaired production of the glycoprotein hormone thrombopoietinwhich is the stimulant for platelet production, may be a trombksitopenia factor to the reduction in circulating platelets. Retrieved from ” https: There is increasing use of immunosuppressants such as mycophenolate mofetil and azathioprine because of their effectiveness.


There is no specific treatment for ITP. The patient was followed-up for 2 years and there was no re-occurence reported.

Immune thrombocytopenic purpura (ITP)

Am Soc Hematol ;— It is recommended that neonates be followed with serial platelet counts for the first few days after birth. When to Contact a Medical Professional.

ITP occurs when certain immune system cells produce antibodies against platelets. Footnotes Source of Support: This is because the underlying autoimmune mechanism that destroyed the patient’s platelets to begin with will also destroy donor platelets.

Hematol Oncol Clin North Am. All the petechial lesions were completely resolved over the neck, arm, and forearms. Chemistry of Plants That Changed the World.

Immune thrombocytopenic purpura (ITP): MedlinePlus Medical Encyclopedia

Retrieved October 16, In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction. Open in a separate window. This page was last edited on 27 Septemberat Nplate is an experimental treatment for stimulating platelet production. Please review our privacy policy. A report of 66 cases. Acute primary ITP is more common in children years of age, with similar incidence between males and females, while the chronic form is usually encountered in adults with median age of years.


Hematoma, idiopathic thrombocytopenic purpura, petechiae, platelets.

With treatment, the chance of remission a symptom-free period is good. Cellular immune mechanisms in autoimmune thrombocytopenic purpura: National Heart, Lung, and Blood Institute — www. The diagnosis of ITP also requires a medical history anamnesisphysical examination, platelet count, and examination of a peripheral blood smear.

Older patients have more severe and rare bleeding manifestations, such as GI bleeding and possibly intracranial hemorrhage secondary to co-morbidities such as hypertension. Pediatr Rev ; Recommendations of the American Society of Hematology. Cellular immune mechanisms in autoimmune thrombocytopenic purpura: Hematol Oncol Clin Nortn Am ; Sekhon SS, Roy V.

Care, Recommendations, and Protecting Practitioners. All medications for ITP are given either orally or IV; intramuscular injection is avoided due to the possibility of causing bleeding into the skin.

The stimulus for auto-antibody production in ITP is probably abnormal T cell activity. Br J Haematol ; Side effects of thrombopoietin receptor agonists include headache, joint or muscle pain, dizziness, nausea or vomiting, and an increased risk of blood clots.