LIQUISOLID COMPACTS PDF

Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.

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Pharmaceutical Sciences Journals Ann Jose ankara escort. December 19, Accepted: It is a prodrug rapidly deesterified during absorption from the gastrointestinal tract to produce an active metabolite, olmesartan [ 7 ]. Spireas S Liquisolid systems and methods of preparing same.

Journal of Pharmaceutical Scienceand Research 3: The lowest liquid factor was obtained for Avicel PHand accordingly, the amount of carrier was higher than other formulations.

A Novel Approach to Solubility Enhancement.

Several researchers have shown that the liquisolid technique is the most promising method for promoting dissolution rate of poorly water-soluble drugs [ 3 — 5 ]. From the results of different batches prepared by three different carriers shown in Table 6it was found that Neusilin proved to be the superior carrier than others.

Introduction As a most discussed but still not completely resolved issue, solubility or dissolution enhancement techniques remain the most vibrant field for the researchers in formulation science.

Moreover, the more vehicle available means an even distribution of the vehicle over the remaining undissolved drug particles that will help in good wetting of the drug during the dissolution step. The maximum liquid load on the carrier material is termed as the liquid load factor Lf. Solubility of CBZ was determined in different non volatile solvents to finalise vehicle having maximum solubility.

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Agri and Aquaculture Journals Dr.

Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement | OMICS International

The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. To this liquid medication, the calculated amount of the carrier was added by continuous mixing in the mortar. To receive news and publication updates for Journal of Drug Delivery, enter your email address in the box below.

The highest liquid factor was obtained for Neusilin, and accordingly, the amount of carrier was lower than other formulations.

Withdrawn samples were filtered through a 0. Select your language of interest to view the total content in your interested language. Inert, preferably water-miscible organic solvent systems with high boiling point and a not highly viscous organic liquisplid system such as propylene glycol, liquid polyethylene glycols, polysorbates, fixed oils, or glycerine are best suitable as liquid vehicles [ 5 ].

Spireas S, Sadu S Enhancement of prednisolone dissolution properties using liquisolid compacts. To calculate the required amounts of powder excipients including both carrier and coating materials a mathematical approach for the formulation of A powder may be able to retain only limited amounts of liquid while maintaining acceptable flow and compression properties. Powder flowability is crucial in the industrial liqquisolid of tablet dosage forms, as a uniform powder stream through hopper confirms uniformity of both tablet weight and drug content.

Patil J Liquisolid Compact Technique: The thermogram showed a sharp endothermic peak at of This indicates that there is no interaction between the drug and excipients.

Formulation and Evaluation of Carbamazepine Liquisolid Compacts Using Novel Carriers

IntJ Pharm PharmSci 2: Can’t read the image? The pronounced effect of the different carriers was not observed on dissolution profile so the flow properties and tensile strength were considered for optimizing the carrier. The excipient and coating material are to be taken into definite ratios so as to retain the accepted amount of liquid to be converted into solid.

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Characteristic peaks of the individual excipients were also retained; also no new peak was found in drug-loaded mixture of the excipients to be formulated in liquisolids.

On the other hand, if a solid water-insoluble drug is formulated, it should be initially dissolved or suspended in suitable nonvolatile solvent system to produce drug solution or drug suspension of desired concentration.

Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement

Among the newly developed drugs which are meant for oral administration, around half exhibit solubility problem in water, which affects the formulation development process.

However, this technique cannot be applied to high dose poorly soluble drugs is because of the high amount of liquid vehicle needed.

The flow property obtained by Neusilin was good and remains unaffected at such low amount. The technique is also applied to design sustained release dosage forms by using hydrophobic carriers. Fujicalin and Neusilin are used as carrier materials instead of Avicel, the liquid adsorption capacity increases by many folds. International Journal of Pharmaceutics Subscribe to Table of Contents Alerts.